Follow sufferers for signs and signs or symptoms of respiratory melancholy and sedation. In case the affected individual is visibly sedated, Appraise the reason for sedation and take into account delaying or omitting daily methadone dosing. Drug interactions Drug interactions could change how you

QT interval prolongation and critical arrhythmia (torsades de pointes) have happened during remedy with methadone. Most scenarios contain individuals getting dealt with for agony with big, several day-to-day doses of methadone, While cases happen to be documented in clients obtaining doses usually u